2-Bromopropionic acid → 2-{5-Chloro-4-[5-chloro-2-(difluoromethyl)phenyl]-2-oxopyridin-1(2H)-yl}propanoic acid
反応式
[Cl:1][C:2]1[C:3]([C:9]2[CH:14]=[C:13]([Cl:15])[CH:12]=[CH:11][C:10]=2[CH:16]([F:18])[F:17])=[CH:4][C:5](=[O:8])[NH:6][CH:7]=1.Br[CH:20]([CH3:24])[C:21]([OH:23])=[O:22]>>[Cl:1][C:2]1[C:3]([C:9]2[CH:14]=[C:13]([Cl:15])[CH:12]=[CH:11][C:10]=2[CH:16]([F:18])[F:17])=[CH:4][C:5](=[O:8])[N:6]([CH:20]([CH3:24])[C:21]([OH:23])=[O:22])[CH:7]=1参加物
3
実験手順
118 mg (0.41 mmol) of 5-chloro-4-[5-chloro-2-(difluoromethyl)phenyl]pyridin-2(1H)-one and 1.5 eq. of 2-bromopropanoic acid (racemate) were reacted according to General Method 4A at 35° C. Yield: 112 mg (76% of theory)
後処理
- customaccording to General Method 4A at 35° C
出典と根拠
- ORDレコード
- ord-f46809968d4f4934871de5b1cc97ab55
- 出典データセット
- uspto-grants-2016_09
- 特許番号
- US09434690B2
反応ノート
読み込み中…