tert-Butyl 2-bromopropanoate → tert-Butyl 2-{5-chloro-4-[5-chloro-2-(trifluoromethyl)phenyl]-2-oxopyridin-1(2H)-yl}propanoate

HRID 56711

反応式

HRID 56711 の反応式
[Cl:1][C:2]1[C:3]([C:9]2[CH:14]=[C:13]([Cl:15])[CH:12]=[CH:11][C:10]=2[C:16]([F:19])([F:18])[F:17])=[CH:4][C:5](=[O:8])[NH:6][CH:7]=1.Br[CH:21]([CH3:29])[C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23]>>[Cl:1][C:2]1[C:3]([C:9]2[CH:14]=[C:13]([Cl:15])[CH:12]=[CH:11][C:10]=2[C:16]([F:17])([F:18])[F:19])=[CH:4][C:5](=[O:8])[N:6]([CH:21]([CH3:29])[C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23])[CH:7]=1

参加物

3

反応物 2

HCID 545327tert-Butyl 2-bromopropanoateHCID 1176050785-Chloro-4-[5-chloro-2-(trifluoromethyl)phenyl]pyridin-2(1H)-one

生成物 1

HCID 117622552tert-Butyl 2-{5-chloro-4-[5-chloro-2-(trifluoromethyl)phenyl]-2-oxopyridin-1(2H)-yl}propanoate

実験手順

123 mg (0.4 mmol) of 5-chloro-4-[5-chloro-2-(trifluoromethyl)phenyl]pyridin-2(1H)-one and 1.05 eq. of tert-butyl 2-bromopropanoate (racemate) were reacted according to General Method 4B at 100° C. Yield: 81 mg (47% of theory)

後処理

  1. customaccording to General Method 4B at 100° C

出典と根拠

ORDレコード
ord-f3bbb966f9b34f40869db107d3d57c46
出典データセット
uspto-grants-2016_09
特許番号
US09434690B2

関連ノート

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