化工社化工社 化学情報印刷レポート · 研究参考用
tert-Butyl 2-bromopropanoate → tert-Butyl 2-{5-chloro-4-[5-chloro-2-(trifluoromethyl)phenyl]-2-oxopyridin-1(2H)-yl}propanoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | tert-Butyl 2-bromopropanoate | HCID 545327 | — |
| 反応物 | 5-Chloro-4-[5-chloro-2-(trifluoromethyl)phenyl]pyridin-2(1H)-one | HCID 117605078 | — |
| 生成物 | tert-Butyl 2-{5-chloro-4-[5-chloro-2-(trifluoromethyl)phenyl]-2-oxopyridin-1(2H)-yl}propanoate | HCID 117622552 | — |
反応手順
123 mg (0.4 mmol) of 5-chloro-4-[5-chloro-2-(trifluoromethyl)phenyl]pyridin-2(1H)-one and 1.05 eq. of tert-butyl 2-bromopropanoate (racemate) were reacted according to General Method 4B at 100° C. Yield: 81 mg (47% of theory)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09434690B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-f3bbb966f9b34f40869db107d3d57c46 |
| 出典メモ | uspto-grants-2016_09 |