2-(2,6-Difluoro-phenyl)-6-nitro-benzo[d][1,3]oxazin-4-one → 6-Amino-2-(2,6-difluoro-phenyl)-benzo[d][1,3]oxazin-4-one

HRID 567680

反応式

HRID 567680 の反応式
[N+:1]([C:4]1[CH:22]=[CH:21][C:7]2[N:8]=[C:9]([C:13]3[C:18]([F:19])=[CH:17][CH:16]=[CH:15][C:14]=3[F:20])[O:10][C:11](=[O:12])[C:6]=2[CH:5]=1)([O-])=O>C(O)(=O)C.O=[Pt]=O>[NH2:1][C:4]1[CH:22]=[CH:21][C:7]2[N:8]=[C:9]([C:13]3[C:14]([F:20])=[CH:15][CH:16]=[CH:17][C:18]=3[F:19])[O:10][C:11](=[O:12])[C:6]=2[CH:5]=1

参加物

4

反応物 1

HCID 212624642-(2,6-Difluoro-phenyl)-6-nitro-benzo[d][1,3]oxazin-4-one

生成物 1

HCID 98603326-Amino-2-(2,6-difluoro-phenyl)-benzo[d][1,3]oxazin-4-one

試薬・触媒・溶媒 2

HCID 345198Adams' catalyst触媒HCID 176Acetic Acid溶媒

実験手順

6-Nitro-2-(2,6-difluoro-phenyl)-benzo[d][1,3]oxazin-4-one (50 mg) was dissolved in acetic acid (5 mL) under N2, PtO2 (2.5 mg) was added and the mixture was hydrogenated with H2 gas. Reaction time 2 h. The reaction mixture was filtered through Hyflo®, which was rinsed afterwards with ethyl acetate. The combined organic phases were evaporated to dryness and subsequently treated three times with toluene followed by evaporation.

後処理

  1. customReaction time 2 h
  2. filtrationThe reaction mixture was filtered through Hyflo®, which
  3. washwas rinsed afterwards with ethyl acetate
  4. customThe combined organic phases were evaporated to dryness
  5. additionsubsequently treated three times with toluene
  6. customfollowed by evaporation

出典と根拠

ORDレコード
ord-d8033a7ca60b434caf3c2f39c77958ee
出典データセット
uspto-grants-2001_01
特許番号
US06180625B2

関連ノート

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