2-(2,6-Difluoro-phenyl)-7-nitro-benzo[d][1,3]oxazin-4-one → 7-Amino-2-(2,6-difluoro-phenyl)-benzo[d][1,3]oxazin-4-one

HRID 567684ノート

反応式

HRID 567684 の反応式
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]2[C:12](=[O:13])[O:11][C:10]([C:14]3[C:19]([F:20])=[CH:18][CH:17]=[CH:16][C:15]=3[F:21])=[N:9][C:8]=2[CH:22]=1)([O-])=O>C(O)(=O)C.O=[Pt]=O>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]2[C:12](=[O:13])[O:11][C:10]([C:14]3[C:15]([F:21])=[CH:16][CH:17]=[CH:18][C:19]=3[F:20])=[N:9][C:8]=2[CH:22]=1

参加物

4

反応物 1

HCID 104477332-(2,6-Difluoro-phenyl)-7-nitro-benzo[d][1,3]oxazin-4-one

生成物 1

HCID 98819927-Amino-2-(2,6-difluoro-phenyl)-benzo[d][1,3]oxazin-4-one

試薬・触媒・溶媒 2

HCID 345198Adams' catalyst触媒HCID 176Acetic Acid溶媒

実験手順

7-Nitro-2-(2,6-difluoro-phenyl)-benzo[d][1,3]oxazin-4-one (0.10 g) was dissolved in acetic acid (10 mL) under N2, PtO2 (5 mg) was added and the mixture was hydrogenated with H2 gas. Reaction time 1 day. The reaction mixture was filtered through Hyflo®, which was rinsed afterwards with ethyl acetate. The combined organic phases were evaporated to dryness and subsequently treated three times with toluene followed by evaporation.

後処理

  1. customReaction time 1 day
  2. filtrationThe reaction mixture was filtered through Hyflo®, which
  3. washwas rinsed afterwards with ethyl acetate
  4. customThe combined organic phases were evaporated to dryness
  5. additionsubsequently treated three times with toluene
  6. customfollowed by evaporation

出典と根拠

ORDレコード
ord-1d1d3e34ba904e49bc320da92f48fc2d
出典データセット
uspto-grants-2001_01
特許番号
US06180625B2

反応ノート

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