Benzyl 2-[3-chloro-5-({[(2R)-1-(cyclopropylmethyl)pyrrolidinyl]methyl}amino)-2-methyl-6-oxo-1(6H)-pyrazinyl]acetate → 2-[3-({[(2R)-1-(cyclopropylmethyl)pyrrolidinyl]methyl}amino)-6-methyl-2-oxo-1(2H)-pyrazinyl]acetic acid hydrochloride
反応式
[Cl:1][C:2]1[N:7]=[C:6]([NH:8][CH2:9][C@H:10]2[CH2:14][CH2:13][CH2:12][N:11]2[CH2:15][CH:16]2[CH2:18][CH2:17]2)[C:5](=[O:19])[N:4]([CH2:20][C:21]([O:23]CC2C=CC=CC=2)=[O:22])[C:3]=1[CH3:31]>[OH-].[Pd+2].[OH-]>[ClH:1].[CH:16]1([CH2:15][N:11]2[CH2:12][CH2:13][CH2:14][C@@H:10]2[CH2:9][NH:8][C:6]2[C:5](=[O:19])[N:4]([CH2:20][C:21]([OH:23])=[O:22])[C:3]([CH3:31])=[CH:2][N:7]=2)[CH2:17][CH2:18]1参加物
3
反応物 1
生成物 1
試薬・触媒・溶媒 1
実験手順
The title compound was prepared by a similar method to preparation 44 from benzyl 2-[3-chloro-5-({[(2R)-1-(cyclopropylmethyl)pyrrolidinyl]methyl}amino)-2-methyl-6-oxo-1(6H)-pyrazinyl]acetate [see preparation 47] and palladium hydroxide to afford the product as a oil, 352 mg, (100%).