2,3-Difluoro-6-nitrophenol → 6-Amino-2,3-difluorophenol

HRID 568006ノート

反応式

HRID 568006 の反応式
[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[C:4]([N+:9]([O-])=O)[C:3]=1[OH:12]>[Pd]>[OH:12][C:3]1[C:2]([F:1])=[C:7]([F:8])[CH:6]=[CH:5][C:4]=1[NH2:9]

参加物

3

反応物 1

HCID 27337452,3-Difluoro-6-nitrophenol

生成物 1

HCID 27784416-Amino-2,3-difluorophenol収率 100.2%

試薬・触媒・溶媒 1

HCID 23938Palladium触媒

実験手順

2,3 difluoro 6-nitrophenol (2 g, 11 mmol) was treated with 10% Pd/C(1 g) at 23° C. The reaction mixture was flushed with hydrogen gas and the reaction was allowed to stir 12 h before it was filtered through celite. The filtrate was concentrated in vacuo to afforded the title compound (1.6 g, 97%). EI-MS m/z 146(M+H)+.

後処理

  1. customThe reaction mixture was flushed with hydrogen gas
  2. filtrationwas filtered through celite
  3. concentrationThe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-607c90368d084e26b1affed4c15e27d2
出典データセット
uspto-grants-2001_01
特許番号
US06180675B2

反応ノート

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