4-Pyridin-4-YL-butyric acid hydrochloride → 4-Piperidine butyric acid hydrochloride

HRID 568112ノート

反応式

HRID 568112 の反応式
[ClH:1].[N:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][C:11]([OH:13])=[O:12])=[CH:4][CH:3]=1>[Pt].O>[ClH:1].[NH:2]1[CH2:7][CH2:6][CH:5]([CH2:8][CH2:9][CH2:10][C:11]([OH:13])=[O:12])[CH2:4][CH2:3]1

参加物

4

反応物 1

HCID 467359454-Pyridin-4-YL-butyric acid hydrochloride

生成物 1

HCID 162170404-Piperidine butyric acid hydrochloride

試薬・触媒・溶媒 2

HCID 23939Platinum触媒HCID 962Water溶媒

実験手順

To the 30% aqueous solution of 4-(4-pyridyl)butanoic acid hydrochloride prepared in step 2 (208.9 kg) and water (145 kg) is added platinum on charcoal (50% wet, 5%, 2.52 kg). The mixture is hydrogenated at about 70° C. under atmospheric pressure over 15 hours and then allowed to cool to ambient temperature. The catalyst is filtered and washed with water (20 kg). The resulting aqueous 16% solution of 4-piperidinebutanoic acid hydrochloride (388.5 kg) is used as is in step 4.

後処理

  1. filtrationThe catalyst is filtered
  2. washwashed with water (20 kg)

出典と根拠

ORDレコード
ord-8115df9208bd454297399a0dc3ad4653
出典データセット
uspto-grants-2001_01
特許番号
US06180759B2

反応ノート

読み込み中…