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Morpholine → HCID 178496768、化合物

HRID 568253
ノート
印刷プレビュー

反応式

HRID 568253 の反応式
[I-].C(OC([N:8]1[C@H:12]([CH2:13][C:14]2[S:18][C:17]3=[CH:19][N:20]([CH2:23][O:24][CH3:25])[C:21]([CH3:22])=[N+:16]3[CH:15]=2)[CH2:11][C@H:10]([S:26][C:27]2[C@H:28]([CH3:44])[C@@H:29]3[C@@H:39]([C@H:40]([OH:42])[CH3:41])[C:38](=[O:43])[N:30]3[C:31]=2[C:32]([O:34]CC=C)=[O:33])[CH2:9]1)=O)C=C.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.N1CCOCC1>C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.C1COCC1.C(O)C>[OH:42][C@@H:40]([C@H:39]1[C:38](=[O:43])[N:30]2[C:31]([C:32]([O-:34])=[O:33])=[C:27]([S:26][C@H:10]3[CH2:11][C@@H:12]([CH2:13][C:14]4[S:18][C:17]5=[CH:19][N:20]([CH2:23][O:24][CH3:25])[C:21]([CH3:22])=[N+:16]5[CH:15]=4)[NH:8][CH2:9]3)[C@H:28]([CH3:44])[C@H:29]12)[CH3:41]
参加物実験手順後処理出典と根拠反応ノート

参加物

7

反応物 3

HCID 8083MorpholineHCID 11776TriphenylphosphineHCID 178459456allyl(1R,5S,6S)-2-[(3S,5S)-1-allyloxycarbonyl-5-[6-methoxymethyl-5-methylimidazo[5,1-b]thiazolium-2-yl]methylpyrrolidin-3-yl]thio-6-((1R)-1-hydroxyethyl)-1-methylcarbapen-2-em-3-carboxylate iodide

生成物 1

HCID 178496768HCID 178496768、化合物収率 6.9%

試薬・触媒・溶媒 3

HCID 178418397
HCID 178418397、化合物
触媒
HCID 702Ethanol溶媒
HCID 8028Tetrahydrofuran溶媒2 回

実験手順

Anhydrous THF (0.5 ml) and 0.5 ml of dry ethanol are added to 47.9 mg of allyl(1R,5S,6S)-2-[(3S,5S)-1-allyloxycarbonyl-5-[6-methoxymethyl-5-methylimidazo[5,1-b]thiazolium-2-yl]methylpyrrolidin-3-yl]thio-6-((1R)-1-hydroxyethyl)-1-methylcarbapen-2-em-3-carboxylate iodide. Triphenylphosphine (5.8 mg), 0.012 ml of morpholine, and 3.2 mg of tetrakis(triphenylphosphine)palladium(0) are successively added in an argon atmosphere at room temperature for 75 min. THF (10 ml) is added thereto, and the resultant precipitate is further washed twice with 3 ml of THF and dried in vacuo to give a yellow powder which is then purified by column chromatography on Cosmosil 40C18-PREP (water-methanol) to give 2.2 mg of the title compound as a colorless flocculent material.

後処理

  1. washthe resultant precipitate is further washed twice with 3 ml of THF
  2. customdried in vacuo
  3. customto give a yellow powder which
  4. customis then purified by column chromatography on Cosmosil 40C18-PREP (water-methanol)

出典と根拠

ORDレコード
ord-9fb70c9db33c4f48bebaf6d157d694cc
出典データセット
uspto-grants-2001_01
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US06180622B2

反応ノート

読み込み中…

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