Dabco → HCID 14099146、化合物
反応式
[NH2:1][C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[N:4][CH:3]=1.N12CCN(CC1)CC2.[CH3:17][CH:18]([N:20]=[C:21]=[O:22])[CH3:19]>CN(C)C=O>[Cl:8][C:6]1[N:5]=[N:4][CH:3]=[C:2]([NH:1][C:21]([NH:20][CH:18]([CH3:19])[CH3:17])=[O:22])[CH:7]=1参加物
5
実験手順
To a stirred solution of 0.8 gram of 4-amino-6-chloro-pyridazine in 30 ml of dimethylformamide is added 0.2 gram of 1,4-diazabicyclo[2.2.2]octane, followed by 0.6 gram of 1-methylethyl isocyanate. The reaction mixture is stirred at ambient temperature for 18 hours, then at 60° C. for six hours. The majority of the dimethylformamide is removed under reduced pressure, and the residue is slurried in water. The resultant solid is collected by filtration and dried to yield N-(6-chloro-4-pyridazinyl)-N'-(1-methylethyl)urea.
後処理
- waitat 60° C. for six hours
- customThe majority of the dimethylformamide is removed under reduced pressure
- filtrationThe resultant solid is collected by filtration
- customdried
出典と根拠
- ORDレコード
- ord-8c2dd2deef404a8cae116669538e97fa
- 出典データセット
- uspto-grants-1988_03
- 特許番号
- US04728355
反応ノート
読み込み中…