Water → Trans-N-(4-bromo-2-methylphenyl)-3-ethoxypropenamide
反応式
[CH2:1]([O:3]/[CH:4]=[CH:5]/[C:6](Cl)=[O:7])[CH3:2].[Br:9][C:10]1[CH:16]=[CH:15][C:13]([NH2:14])=[C:12]([CH3:17])[CH:11]=1.O>N1C=CC=CC=1>[Br:9][C:10]1[CH:16]=[CH:15][C:13]([NH:14][C:6](=[O:7])/[CH:5]=[CH:4]/[O:3][CH2:1][CH3:2])=[C:12]([CH3:17])[CH:11]=1参加物
5
実験手順
Trans-3-ethoxypropenoyl chloride (0.74 g) was added at 0° to a stirred solution of 4-bromo-2-methylaniline (0.93 g) in pyridine (10 cm3). After 0.5 hours water (40 cm3) was added, the solid material was filtered off, washed with water (30 cm3) and dried. The product was recrystallised from ethyl acetate to afford trans-N-(4-bromo-2-methylphenyl)-3-ethoxypropenamide, m.p. 163°-164°, (1.3 g).
後処理
- filtrationthe solid material was filtered off
- washwashed with water (30 cm3)
- customdried
- customThe product was recrystallised from ethyl acetate
出典と根拠
- ORDレコード
- ord-59ac6bb072e24b90ba5395cc648529d7
- 出典データセット
- uspto-grants-1988_03
- 特許番号
- US04728654
反応ノート
読み込み中…