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Hydroxyamine hydrochloride → 2,3-Dichloro-4-hydroxy-4'-fluorobenzophenone oxime
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydroxyamine hydrochloride | HCID 443297 | — |
| 反応物 | 2,3-Dichloro-4-hydroxy-4'-fluorobenzophenone | HCID 13015707 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 生成物 | 2,3-Dichloro-4-hydroxy-4'-fluorobenzophenone oxime | HCID 136393681 | — |
反応手順
To a solution of 35 g of 2,3-dichloro-4-hydroxy-4'-fluorobenzophenone in 250 ml pyridine, 34.6 g of hydroxylamine HCl is added. The mixture is refluxed for 4 hours. The pyridine is evaporated in vacuo. The residue is partitioned between 5% HCl and ethyl acetate. The ethyl acetate extract is washed with water, dried over Na2SO4 and evaporated to give 2,3-dichloro-4-hydroxy-4'-fluorobenzophenone oxime as a mixture of isomers, mp 150°-156° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04728662 |
| 出典データセット | uspto-grants-1988_03 |
| ORD ID | ord-f2a7955c2e234f91b773f6e7a2ea1a92 |
| 出典メモ | uspto-grants-1988_03 |