反应详情

To a solution of 35 g of 2,3-dichloro-4-hydroxy-4'-fluorobenzophenone in 250 ml pyridine, 34.6 g of hydroxylamine HCl is added. The mixture is refluxed for 4 hours. The pyridine is evaporated in vacuo. The residue is partitioned between 5% HCl and ethyl acetate. The ethyl acetate extract is washed with water, dried over Na2SO4 and evaporated to give 2,3-dichloro-4-hydroxy-4'-fluorobenzophenone oxime as a mixture of isomers, mp 150°-156° C.

1. temperatureThe mixture is refluxed for 4 hours
2. customThe pyridine is evaporated in vacuo
3. customThe residue is partitioned between 5% HCl and ethyl acetate
4. extractionThe ethyl acetate extract
5. washis washed with water
6. dry with materialdried over Na2SO4
7. customevaporated