Sodium Iodide → 3-Methoxyphenethyl iodide
反応式
CS(O[CH2:6][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([O:14][CH3:15])[CH:9]=1)(=O)=O.[I-:16].[Na+]>CC(C)=O>[CH3:15][O:14][C:10]1[CH:9]=[C:8]([CH:13]=[CH:12][CH:11]=1)[CH2:7][CH2:6][I:16]参加物
4
実験手順
To a flask under argon was added 14.6 g (0.0634 mole) 2-(3-methoxyphenyl)ethyl methanesulfonate in 400 ml of acetone and 36.5 g (0.243 mole) of sodium iodide. The reaction mixture was refluxed for 2.5 hr. The acetone was evaporated in vacuo and the residue dissolved in ether. The ether was washed with water, sodium bicarbonate, sodium thiosulfate, water and brine, dried over MgSO4, and evaporated in vacuo to give a light green oil. Distillation in a Kugelrohr apparatus gave 14.6 g of the desired product as a clear oil.
後処理
- temperatureThe reaction mixture was refluxed for 2.5 hr
- customThe acetone was evaporated in vacuo
- dissolutionthe residue dissolved in ether
- washThe ether was washed with water, sodium bicarbonate, sodium thiosulfate, water and brine
- dry with materialdried over MgSO4
- customevaporated in vacuo
- customto give a light green oil
- distillationDistillation in a Kugelrohr apparatus
出典と根拠
- ORDレコード
- ord-2e268c1b31fb4351950561eda9728d02
- 出典データセット
- uspto-grants-1988_03
- 特許番号
- US04729994
反応ノート
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