Water → 4-(2-Iodoethyl)-1,2-dimethoxybenzene

HRID 568782ノート

反応式

HRID 568782 の反応式
CS(O[CH2:6][CH2:7][C:8]1[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[C:10]([O:16][CH3:17])[CH:9]=1)(=O)=O.[I-:18].[Na+].O>CC(C)=O>[CH3:17][O:16][C:10]1[CH:9]=[C:8]([CH:13]=[CH:12][C:11]=1[O:14][CH3:15])[CH2:7][CH2:6][I:18]

参加物

5

反応物 3

HCID 962WaterHCID 5238Sodium IodideHCID 112076823,4-Dimethoxyphenethyl methanesulfonate

生成物 1

HCID 5970224-(2-Iodoethyl)-1,2-dimethoxybenzene収率 92.6%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

To a flask was added 21.2 g (0.078 mole) of 2-(3,4-dimethoxyphenyl)ethyl methanesulfonate and 44.65 g (0.3 mole) of sodium iodide in 420 ml of acetone. The solution was refluxed for 2 hr, poured into water, washed with brine, dried over MgSO4, and evaporated to give 21.1 g of a yellow oil. The oil was recrystallized in MeOH to give 17.1 g of product, mp 43°-46° C.

後処理

  1. temperatureThe solution was refluxed for 2 hr
  2. washwashed with brine
  3. dry with materialdried over MgSO4
  4. customevaporated

出典と根拠

ORDレコード
ord-57623c082a6a4f979b0f7fd2560088e7
出典データセット
uspto-grants-1988_03
特許番号
US04729994

反応ノート

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