反応式
[C:1]([CH2:3][C@H:4]1[O:9][C:8]([CH3:11])([CH3:10])[O:7][C@@H:6]([CH2:12][C:13]([OH:15])=[O:14])[CH2:5]1)#[N:2].N12CCCN=C1CC[CH2:19][CH2:18][CH2:17]2.IC(C)C>C(#N)C.C(OCC)C>[C:1]([CH2:3][C@H:4]1[O:9][C:8]([CH3:11])([CH3:10])[O:7][C@@H:6]([CH2:12][C:13]([O:15][CH:18]([CH3:19])[CH3:17])=[O:14])[CH2:5]1)#[N:2]参加物
6
反応物 3
生成物 1
試薬・触媒・溶媒 2
実験手順
To a solution of (±)-cis-6-(cyanomethyl)-2,2-dimethyl-1,3-dioxane-4-acetic acid, 0.6 g (3 mmol), in acetonitrile, 2 mL, is added 1,8-diazabicyclo[5.4.0]-undec-7-ene (DBU), 0.45 mL (3 mmol), and 2-iodopropane, 0.33 mL (3.3 mmol). The solution is stirred overnight at room temperature, diluted with diethyl ether, washed with brine, and dried (magnesium sulfate). Flash chromatography provides 0.55 g of (±)-cis-1-methylethyl 6-(cyanomethyl)-2,2-dimethyl-1,3-dioxane-4-acetate.
後処理
- washwashed with brine
- dry with materialdried (magnesium sulfate)
出典と根拠
- ORDレコード
- ord-3e866dd73b724ce1babaa729046e5dfa
- 出典データセット
- uspto-grants-1993_09
- 特許番号
- US05245047
関連ノート
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