Hydrochloric Acid → 2-Sulfamoylthieno[3,2-c]pyridin-4(5H)-one

HRID 569060ノート

反応式

HRID 569060 の反応式
[S:1]([C:5]1[S:13][C:12]2[CH:11]=[CH:10][N:9]=[C:8](Cl)[C:7]=2[CH:6]=1)(=[O:4])(=[O:3])[NH2:2].Cl.[OH-:16].[Na+]>O>[S:1]([C:5]1[S:13][C:12]2[CH:11]=[CH:10][NH:9][C:8](=[O:16])[C:7]=2[CH:6]=1)(=[O:4])(=[O:3])[NH2:2]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 201485834-Chlorothieno[3,2-c]pyridine-2-sulfonamide

生成物 1

HCID 201485572-Sulfamoylthieno[3,2-c]pyridin-4(5H)-one収率 66%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
100 °C

実験手順

A solution of 2-sulfamoyl-4-chlorothieno[3,2-c]pyridine (0.87 g, 3.5 mmol) in 10 N sodium hydroxide (1.8 ml) diluted with water (7 ml) was heated at 100° C. for 5-10 hours. After cooling the reaction and acidification with concentrated hydrochloric acid, the precipitated product was collected by filtration. Recrystallization from hot dimethyl sulfoxide by dilution with ethanol gives 0.53 g (66% yield) of product; m.p. 299°-301° C.

後処理

  1. temperatureAfter cooling
  2. filtrationthe precipitated product was collected by filtration
  3. customRecrystallization from hot dimethyl sulfoxide by dilution with ethanol

出典と根拠

ORDレコード
ord-ef57163a5e684e049f1b51872253b2cb
出典データセット
uspto-grants-1988_03
特許番号
US04731368

反応ノート

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