Benzoyl chloride → HCID 13670754、化合物
反応式
[NH2:1][C:2]1[S:3][C:4]2[CH2:10][CH:9]([N:11]([CH3:13])[CH3:12])[CH2:8][CH2:7][C:5]=2[N:6]=1.[C:14]([Cl:22])(=[O:21])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>N1C=CC=CC=1>[ClH:22].[ClH:22].[C:14]([NH:1][C:2]1[S:3][C:4]2[CH2:10][CH:9]([N:11]([CH3:13])[CH3:12])[CH2:8][CH2:7][C:5]=2[N:6]=1)(=[O:21])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1参加物
4
実験手順
3.0 g (15 mMol) of 2-amino-6-dimethylamino4,5,6,7-tetrahydro-benzthiazole are dissolved in 15 ml of pyridine and 2.1 g (15 mMol) of benzoylchloride are added dropwise. After standing overnight the mixture is concentrated, mixed with soda solution and extracted with chloroform. The chloroform extract is concentrated and then chromatographed on silica gel (eluant: methylenechloride/methanol=9/1). The isolated base (melting point 174° C.) is dissolved in acetone and the dihydrochloride is precipitated with isopropanolic hydrochloric acid.