Methanol → HCID 13362007、化合物

反応式

[CH2:1]([N:8]1[C:12](=[O:13])[CH2:11][CH:10]([C:14](OC)=[O:15])[CH:9]1[C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([O:24][CH3:25])[CH:19]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.CO.[BH4-].[Na+]>O>[CH2:1]([N:8]1[CH:9]([C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([O:24][CH3:25])[CH:19]=2)[CH:10]([CH2:14][OH:15])[CH2:11][C:12]1=[O:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

反応条件

温度: 50 °C

実験手順

To 42.1 gm. of methyl 1-benzyl-2-(3-methoxyphenyl)-5-oxopyrrolidin-3-carboxylate in 436 ml. of absolute methanol was slowly added at -10° to -5°, 37.9 gm. of sodium borohydride. The reaction mixture was left in the ice bath until it came to ambient temperature. Concentration in vacuo provided a white gum which was suspended in water and heated to 50° C. The gum was extracted with chloroform, dried (Na2SO4), filtered, and concentrated in vacuo to yield 22.8 gm. of yellow oil.