反応式
N1C=CC=CC=1.[Cl:7][C:8]1[CH:18]=[C:17]([Cl:19])[CH:16]=[CH:15][C:9]=1[O:10][CH2:11][C:12](Cl)=[O:13].[NH2:20][C:21]1[N:25]([C:26]2[C:31]([Cl:32])=[CH:30][C:29]([C:33]([F:36])([F:35])[F:34])=[CH:28][C:27]=2[Cl:37])[N:24]=[CH:23][CH:22]=1>ClCCl>[Cl:7][C:8]1[CH:18]=[C:17]([Cl:19])[CH:16]=[CH:15][C:9]=1[O:10][CH2:11][C:12]([NH:20][C:21]1[N:25]([C:26]2[C:31]([Cl:32])=[CH:30][C:29]([C:33]([F:34])([F:36])[F:35])=[CH:28][C:27]=2[Cl:37])[N:24]=[CH:23][CH:22]=1)=[O:13]参加物
実験手順
2.2 ml (0.0275 mol) of anhydrous pyridine and 6.7 g (0.027 mol) of 96.3 percent strength 2,4-dichlorophenoxyacetyl chloride are added successively to 8 g (0.027 mol) of 5-amino-1-(2,6-dichloro-4-trifluoromethylphenyl)-pyrazole (cf. U.S. Pat. No. 4,614,533, supra, in 60 ml of dichloromethane with stirring at 0° C. to 5° C. and the mixture is stirred for 16 hours at room temperature. The mixture is worked up by adding 100 ml of dichloromethane, washing successively with dilute hydrochloric acid, saturated sodium bicarbonate solution and saturated sodium chloride solution, drying the organic phase over magnesium sulphate and removing the solvent in vacuo. 12.7 g (94.3% of theory) of 5-(2,4-dichlorophenoxyacetamido)-1-(2,6-dichloro-4-trifluoromethylphenyl)-pyrazole of melting point 167° C.-180° C. are obtained.
後処理
- washwashing successively with dilute hydrochloric acid, saturated sodium bicarbonate solution and saturated sodium chloride solution
- dry with materialdrying the organic phase over magnesium sulphate
- customremoving the solvent in vacuo
出典と根拠
- ORDレコード
- ord-55b6c277f7e24b56919f2ba491507085
- 出典データセット
- uspto-grants-1988_03
- 特許番号
- US04734125
関連ノート
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