4-Chloroisatoic anhydride → 2-amino-N-(4-bromo-2-fluorobenzyl)-4-chlorobenzamide

HRID 569808ノート

反応式

HRID 569808 の反応式
[Cl:1][C:2]1[CH:13]=[CH:12][C:5]2[C:6](=[O:11])OC(=O)[NH:9][C:4]=2[CH:3]=1.[Br:14][C:15]1[CH:22]=[CH:21][C:18]([CH2:19][NH2:20])=[C:17]([F:23])[CH:16]=1>O1CCCC1>[NH2:9][C:4]1[CH:3]=[C:2]([Cl:1])[CH:13]=[CH:12][C:5]=1[C:6]([NH:20][CH2:19][C:18]1[CH:21]=[CH:22][C:15]([Br:14])=[CH:16][C:17]=1[F:23])=[O:11]

参加物

4

反応物 2

HCID 3291054-Chloroisatoic anhydrideHCID 3770848(4-Bromo-2-fluorophenyl)methanamine

生成物 1

HCID 144589862-amino-N-(4-bromo-2-fluorobenzyl)-4-chlorobenzamide収率 79.9%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A mixture of 7-chloro-2H-3,1-benzoxazine-2,4(1H)dione (18.4 g) and 4-bromo-2-fluorobenzylamine (26 g) in tetrahydrofuran (200 ml) was refluxed for 15 minutes. After cooling, tetrahydrofuran was evaporated to give a residue. Recrystallization from isopropyl ether gave 2-amino-N-(4-bromo-2-fluorobenzyl)-4-chlorobenzamide (26.6 g).

後処理

  1. temperaturewas refluxed for 15 minutes
  2. temperatureAfter cooling
  3. customtetrahydrofuran was evaporated
  4. customto give a residue
  5. customRecrystallization from isopropyl ether

出典と根拠

ORDレコード
ord-403b2c40189f42a6a301c16ed594a458
出典データセット
uspto-grants-1988_03
特許番号
US04734419

反応ノート

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