Glycine → N-Heptanoylglycine
反応式
[NH2:1][CH2:2][C:3]([OH:5])=[O:4].[C:6](Cl)(=[O:13])[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12].[OH-].[Na+]>O.CCOCC>[C:6]([NH:1][CH2:2][C:3]([OH:5])=[O:4])(=[O:13])[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12]参加物
6
実験手順
Glycine (1.5 g, 20 mmol) and heptanoyl chloride (22 mmol) were reacted in the presence of NaOH (40 mmol) in a mixture of water and ether using the method described in Example 5. The crude product was recrystallized from EtOAc (30 ml) to give title compound (2.71 g, 72%), m.p. 98°-100° C.
後処理
- customThe crude product was recrystallized from EtOAc (30 ml)
出典と根拠
- ORDレコード
- ord-82af9659471b4e5db4f112684cfee59c
- 出典データセット
- uspto-grants-1988_03
- 特許番号
- US04734424
反応ノート
読み込み中…