Hydrogen Bromide → 6-Chloro-7-hydroxy-3,4-dihydrocarbostyril
反応式
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[O:12]C)[NH:8][C:7](=[O:14])[CH2:6][CH2:5]2.Br>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[OH:12])[NH:8][C:7](=[O:14])[CH2:6][CH2:5]2参加物
3
実験手順
The thus obtained 30 g of 6-chloro-7-methoxy-3,4-dihydrocarbostyril are dispersed in 300 ml of 47%-hydrobromic acid aqueous solution and heated for 4 hours under refluxing condition. After cooling of the reaction mixture, the insoluble matter is separated by filtration, washed with water and dried. Recrystallization from methanol-chloroform obtains 25 g of 6-chloro-7-hydroxy-3,4-dihydrocarbostyril in the form of colorless needle-like crystals with a melting point of 264°-266° C.
後処理
- temperatureheated for 4 hours
- temperatureunder refluxing condition
- temperatureAfter cooling of the reaction mixture
- customthe insoluble matter is separated by filtration
- washwashed with water
- customdried
- customRecrystallization from methanol-chloroform
出典と根拠
- ORDレコード
- ord-251c2e40210443f89660a946d76ce883
- 出典データセット
- uspto-grants-1988_03
- 特許番号
- US04734416
反応ノート
読み込み中…