Diethyl Ether → 3-(4-fluorophenyl)-1H-pyrazol-5-ol

HRID 570125ノート

反応式

HRID 570125 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=O)[CH2:9][C:10]([O:12]C)=O)=[CH:4][CH:3]=1.O.[NH2:16][NH2:17].C(OCC)C>C(O)(=O)C>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([OH:12])[NH:17][N:16]=2)=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 3283Diethyl EtherHCID 24654Hydrazine hydrate (1:1)HCID 579425Methyl 4-fluorobenzoylacetate

生成物 1

HCID 1785156243-(4-fluorophenyl)-1H-pyrazol-5-ol

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

A mixture of methyl 3-(4-fluorophenyl)-3-oxopropanoate (10.0 g, 0.051 mol) and hydrazine hydrate (1.1 eq, 2.8 g, 0.056 mol) in 20 mL glacial acetic acid is heated 3 h under reflux. The resulting suspension is cooled down and 10 mL diethyl ether is added. The precipitate is filtered off, dried in vacuo and 9 g (100%) of 3-(4-fluorophenyl)-1H-pyrazol-5-ol are obtained as white solid.

後処理

  1. temperatureis heated 3 h
  2. temperatureunder reflux
  3. temperatureThe resulting suspension is cooled down
  4. filtrationThe precipitate is filtered off
  5. dry with materialdried in vacuo and 9 g (100%) of 3-(4-fluorophenyl)-1H-pyrazol-5-ol
  6. customare obtained as white solid

出典と根拠

ORDレコード
ord-1d076a840bc2483f9538a4bf5b21a9e0
出典データセット
uspto-grants-2015_05
特許番号
US09023844B2

反応ノート

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