(Phenylmethoxy)acetaldehyde → 1-(Benzyloxy)pent-4-en-2-ol
反応式
[CH2:1]([O:8][CH2:9][CH:10]=[O:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:12]([Mg]Cl)[CH:13]=[CH2:14]>C1COCC1>[CH2:1]([O:8][CH2:9][CH:10]([OH:11])[CH2:14][CH:13]=[CH2:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1参加物
4
反応条件
- 温度
- 0 °C
実験手順
2-(Benzyloxy)acetaldehyde (5 g, 33.3 mmol) in dry THF (10 mL) was added dropwise to a stirred and cooled solution of allylmagnesium chloride (25 mL, 2 M in THF, 50 mmol) in THF (100 mL) at −78° C. After the addition, the solution was allowed to warm to 0° C. and quenched with saturated NH4Cl solution. After standard aqueous work up, the residue was purified over silica using EtOAc and hexane to give 1-(benzyloxy)pent-4-en-2-ol (11).
後処理
- additionAfter the addition
- customquenched with saturated NH4Cl solution
- customAfter standard aqueous work up, the residue was purified over silica
出典と根拠
- ORDレコード
- ord-2ecd7da9568442ffabf69095bebf3b14
- 出典データセット
- uspto-grants-2015_05
- 特許番号
- US09023839B2
反応ノート
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