1H-Pyrazolo(3,4-d)pyrimidine → HCID 178506576、化合物
反応式
[NH:1]1[C:5]2=[N:6][CH:7]=[N:8][CH:9]=[C:4]2[CH:3]=[N:2]1.[I:10]N1C(=O)CCC1=O>CN(C=O)C>[I:10][C:3]1[C:4]2[C:5](=[N:6][CH:7]=[N:8][CH:9]=2)[NH:1][N:2]=1参加物
4
反応条件
- 温度
- 80 °C
実験手順
520 mg (4.331 mmol) of 1H-pyrazolo[3,4-d]pyrimidine and 1.461 g (6.496 mmol) of N-iodosuccinimide were dissolved in 10 ml of DMF and the mixture was heated at 80° C. for 3 h. After cooling, the mixture was concentrated on a rotary evaporator and the residue was stirred with dichloromethane, filtered off with suction and dried under high vacuum. 569 mg (53% of theory) of the target compound were obtained.
後処理
- temperatureAfter cooling
- concentrationthe mixture was concentrated on a rotary evaporator
- filtrationfiltered off with suction
- customdried under high vacuum
- custom569 mg (53% of theory) of the target compound were obtained
出典と根拠
- ORDレコード
- ord-a880a7ad8070471db5b646bbf75b8202
- 出典データセット
- uspto-grants-2015_05
- 特許番号
- US09023849B2
反応ノート
読み込み中…