Potassium Carbonate → 2,6-Dichloro-9-cyclopropylpurine
反応式
[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([NH:6][CH:7]=[N:8]2)=[C:4]([Cl:11])[N:3]=1.C(=O)([O-])[O-].[K+].[K+].[CH:18]1(I)[CH2:20][CH2:19]1>CS(C)=O>[CH:18]1([N:8]2[CH:7]=[N:6][C:5]3[C:9]2=[N:10][C:2]([Cl:1])=[N:3][C:4]=3[Cl:11])[CH2:20][CH2:19]1参加物
5
実験手順
2,6-Dichloropurine (1 mmol), powdered potassium carbonate (4 mmol) and cyclopropyliodide were vigorously stirred in 5 mL DMSO overnight. After evaporation of the solvent the product was extracted (water/diethylether) and purified by column chromatography (silicagel/1% MeOH in CHCl3). Crystallization from diethylether gave product in 35% yield, mp 121-124° C.
後処理
- customAfter evaporation of the solvent the product
- extractionwas extracted (water/diethylether)
- custompurified by column chromatography (silicagel/1% MeOH in CHCl3)
- customCrystallization from diethylether
- customgave product in 35% yield, mp 121-124° C.
出典と根拠
- ORDレコード
- ord-20cd74ffb7cb48129122e08aefcfdb27
- 出典データセット
- uspto-grants-2015_05
- 特許番号
- US09023857B2
反応ノート
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