Trifluoroacetic acid → 6-amino-2-(ethylsulfanyl)-3-[4-(2,2,2-trifluoroethoxy)phenyl]pyrimidin-4(3H)-one
反応式
COC1C=C(OC)C=CC=1C[N:6](CC1C=CC(OC)=CC=1OC)[C:7]1[N:12]=[C:11]([S:13][CH2:14][CH3:15])[N:10]([C:16]2[CH:21]=[CH:20][C:19]([O:22][CH2:23][C:24]([F:27])([F:26])[F:25])=[CH:18][CH:17]=2)[C:9](=[O:28])[CH:8]=1.C1(OC)C=CC=CC=1.FC(F)(F)C(O)=O>>[NH2:6][C:7]1[N:12]=[C:11]([S:13][CH2:14][CH3:15])[N:10]([C:16]2[CH:17]=[CH:18][C:19]([O:22][CH2:23][C:24]([F:26])([F:27])[F:25])=[CH:20][CH:21]=2)[C:9](=[O:28])[CH:8]=1参加物
4
実験手順
A mixture of 6-[bis(2,4-dimethoxybenzyl)amino]-2-(ethylsulfanyl)-3-[4-(2,2,2-trifluoroethoxy)phenyl]pyrimidin-4(3H)-one (0.68 g), anisole (0.459 mL) and trifluoroacetic acid (7 mL) was stirred at room temperature for 1 hr. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (0.19 g).
後処理
- customThe solvent was evaporated under reduced pressure
- customthe residue was purified by silica gel column chromatography (ethyl acetate/hexane)
出典と根拠
- ORDレコード
- ord-6718514f11f34fa5b984472ce169d9e7
- 出典データセット
- uspto-grants-2015_05
- 特許番号
- US09023858B2
反応ノート
読み込み中…