Hydrochloric Acid → 4-[3-Cyano-4-(2-hydroxyphenyl)pyrrole-1-yl]-2-hydroxy benzoic acid ethyl ester

HRID 570841ノート

反応式

HRID 570841 の反応式
[CH2:1]([O:3][C:4](=[O:29])[C:5]1[CH:10]=[CH:9][C:8]([N:11]2[CH:15]=[C:14]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[OH:22])[C:13]([C:23]#[N:24])=[CH:12]2)=[CH:7][C:6]=1[O:25]COC)[CH3:2].O1CCCC1.C(O)C.Cl>O>[CH2:1]([O:3][C:4](=[O:29])[C:5]1[CH:10]=[CH:9][C:8]([N:11]2[CH:15]=[C:14]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[OH:22])[C:13]([C:23]#[N:24])=[CH:12]2)=[CH:7][C:6]=1[OH:25])[CH3:2]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 8028TetrahydrofuranHCID 594776664-[3-Cyano-4-(2-hydroxyphenyl)pyrrole-1-yl]-2-methoxymethoxy benzoic acid ethyl ester

生成物 1

HCID 685063884-[3-Cyano-4-(2-hydroxyphenyl)pyrrole-1-yl]-2-hydroxy benzoic acid ethyl ester収率 50.7%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
70 °C

実験手順

To a solution of 4-[3-cyano-4-(2-hydroxyphenyl)pyrrole-1-yl]-2-methoxymethoxy benzoic acid ethyl ester (0.12 g) in a mixed solvent of tetrahydrofuran (3 mL) and ethanol (5 mL) was added 2 mol/L hydrochloric acid (2 mL), and this mixture was stirred at 70° C. for 18 hours. To this reaction mixture was added water, the precipitated solid was collected by filtration, and this solid was washed with water, dried under reduced pressure at 50° C. to give the title compound (0.054 g).

後処理

  1. filtrationthe precipitated solid was collected by filtration
  2. washthis solid was washed with water
  3. customdried under reduced pressure at 50° C.

出典と根拠

ORDレコード
ord-23dbfa3f5ff04ddca4916344e971e926
出典データセット
uspto-grants-2015_05
特許番号
US09023882B2

反応ノート

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