Bromopyruvic Acid → 3-(Imino(3-methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazin-8-yl)methylthio)-2-oxopropanoic acid

HRID 570927

反応式

HRID 570927 の反応式
Br[CH2:2][C:3](=[O:7])[C:4]([OH:6])=[O:5].[CH3:8][N:9]1[C:14](=[O:15])[N:13]2[CH:16]=[N:17][C:18]([C:19](=[S:21])[NH2:20])=[C:12]2[N:11]=[N:10]1>C(#N)C>[NH:20]=[C:19]([C:18]1[N:17]=[CH:16][N:13]2[C:14](=[O:15])[N:9]([CH3:8])[N:10]=[N:11][C:12]=12)[S:21][CH2:2][C:3](=[O:7])[C:4]([OH:6])=[O:5]

参加物

4

反応物 2

HCID 70684Bromopyruvic AcidHCID 33528803-Methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carbothioamide

生成物 1

HCID 668316143-(Imino(3-methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazin-8-yl)methylthio)-2-oxopropanoic acid

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

To a solution of 3-bromopyruvic acid (1.388 g; 8.3 mmol) in dry acetonitrile (20 mL) was added 3-methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carbothioamide (1.000 g; 4.8 mmol). The mixture was stirred at room temperature overnight, and then concentrated under reduced pressure. The residue was washed with DCM (3×15 mL) and diethyl ether (2×20 mL) and the pale yellow solid (1.20 g; 84%) was used without further purification.

後処理

  1. concentrationconcentrated under reduced pressure
  2. washThe residue was washed with DCM (3×15 mL) and diethyl ether (2×20 mL)
  3. customthe pale yellow solid (1.20 g; 84%) was used without further purification

出典と根拠

ORDレコード
ord-972ba512b6a84a0d8028cbf3c9462686
出典データセット
uspto-grants-2015_05
特許番号
US09024018B2

関連ノート

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