3-Mercaptopropionic Acid → Poly(difluoromethylene), alpha-(2-((2-carboxyethyl)thio)ethyl)-omega-fluoro-

温度

60 °C

A 100 mL stainless steel Pan reactor was charged with azobisisobutyronitrile (AIBN, 0.231 g, 1.41 mmol), toluene (45 mL), 3-mercaptopropionic acid (3.40 g, 32.0 mmol), and octanophenone (526.2 mg) as an internal standard and was purged and pressure checked with nitrogen. The reactor was cooled with dry ice and the 3,3,3-trifluoropropene (3.1 g, 32.3 mmol) was condensed into the reactor. The ice bath was removed and the reactor heated to 60° C. and stirred for 27 hours. The internal yield of the reaction was determined to be 80% by use of the octanophenone internal standard. The pressure was released and the crude mixture removed from the reactor. The mixture was concentrated by rotary evaporation and 50 mL of 10% sodium hydroxide was added. The solution was washed with methyl tert-butylether (50 mL) then acidified to pH˜1 with 6 N hydrochloric acid. The product was extracted with 100 mL methyl tert-butylether, dried over magnesium sulfate (MgSO4), filtered, and concentrated to give the crude titled compound as an oil (5.34 g, 26.4 mmol, 83%, 87.5 area % on GC): 1H NMR (400 MHz, CDCl3) δ 2.83 (td, J=7.1, 0.9 Hz, 2H), 2.76-2.64 (m, 4H), 2.47-2.30 (m, 2H); 13C NMR (101 MHz, CDCl3) δ 177.68, 125.91 (q, J=277.1 Hz), 34.58 (q, J=28.8 Hz), 34.39, 26.63, 24.09 (q, J=3.3 Hz).; 19F NMR (376 MHz, CDCl3) δ −66.49.

1. customwas purged
2. temperatureThe reactor was cooled with dry ice
3. customcondensed into the reactor
4. customThe ice bath was removed
5. customthe crude mixture removed from the reactor
6. concentrationThe mixture was concentrated by rotary evaporation and 50 mL of 10% sodium hydroxide
7. additionwas added
8. washThe solution was washed with methyl tert-butylether (50 mL)
9. extractionThe product was extracted with 100 mL methyl tert-butylether
10. dry with materialdried over magnesium sulfate (MgSO4)
11. filtrationfiltered
12. concentrationconcentrated

ORDレコード

ord-881004c2841b43a7865f559ef683daae

出典データセット

uspto-grants-2016_09

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US09434712B2