Sodium Hydroxide → 2-(5-methoxy-1H-indol-1-yl)acetic acid
反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[N:8]([CH2:12][C:13]([O:15]C)=[O:14])[CH:7]=[CH:6]2.[OH-].[Na+]>CO>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[N:8]([CH2:12][C:13]([OH:15])=[O:14])[CH:7]=[CH:6]2参加物
4
実験手順
To a solution of methyl 2-(5-methoxy-1H-indol-1-yl)acetate (745 mg, 3.40 mmol) in MeOH (20 ml), aqueous 4N sodium hydroxide (935 μl, 3.74 mmol) was slowly added and the reaction was stirred at room temperature for 1 hour. The solvent was removed and the residue was partitioned between ethyl acetate and water. The aqueous phase was acidified with 2.5M HCl and extracted with ethyl acetate. This organic phase was washed with brine, dried over Na2SO4 and evaporated to dryness to give the title compound (510 mg, 2.485 mmol, 73% yield). MS/ESI+ 206.1 [MH]+.
後処理
- customThe solvent was removed
- customthe residue was partitioned between ethyl acetate and water
- extractionextracted with ethyl acetate
- washThis organic phase was washed with brine
- dry with materialdried over Na2SO4
- customevaporated to dryness
出典と根拠
- ORDレコード
- ord-a64d57c7fb974333b8f93c6ce68f49a9
- 出典データセット
- uspto-grants-2015_05
- 特許番号
- US09024027B2
反応ノート
読み込み中…