HCID 43152087、化合物 → Methyl 2-(5-amino-1H-indol-1-yl)acetate
反応式
[N+:1]([C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[N:9]([CH2:13][C:14]([O:16][CH3:17])=[O:15])[CH:8]=[CH:7]2)([O-])=O>CO.O=[Pt]=O>[NH2:1][C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[N:9]([CH2:13][C:14]([O:16][CH3:17])=[O:15])[CH:8]=[CH:7]2参加物
4
実験手順
To a solution of methyl 2-(5-nitro-1H-indol-1-yl)acetate (830 mg, 3.54 mmol) in MeOH (50 ml), a catalytic amount of PtO2 was added, and the mixture was reacted under H2 atmosphere in a Parr apparatus at 30 psi for 15 minutes. The catalyst was filtered off, the solvent was removed and crude methyl 2-(5-amino-1H-indol-1-yl)acetate was obtained and was used in the next step without any additional purification (730 mg, 3.54 mmol, quantitative yield). MS/ESI+ 205.2 [MH]+.
後処理
- customthe mixture was reacted under H2 atmosphere in a Parr apparatus at 30 psi for 15 minutes
- filtrationThe catalyst was filtered off
- customthe solvent was removed
出典と根拠
- ORDレコード
- ord-579a4f4f4a1847b69bc8c412fdf13123
- 出典データセット
- uspto-grants-2015_05
- 特許番号
- US09024027B2
反応ノート
読み込み中…