Sodium hydride → Methyl 2-(5,5-dimethyl-5'-nitro-2'-oxospiro[[1,3]dioxane-2,3'-indoline]-1'-yl)acetate

HRID 571226ノート

反応式

HRID 571226 の反応式
[CH3:1][C:2]1([CH3:20])[CH2:19][O:18][C:5]2([C:13]3[C:8](=[CH:9][CH:10]=[C:11]([N+:14]([O-:16])=[O:15])[CH:12]=3)[NH:7][C:6]2=[O:17])[O:4][CH2:3]1.[H-].[Na+].Br[CH2:24][C:25]([O:27][CH3:28])=[O:26]>CN(C=O)C>[CH3:1][C:2]1([CH3:20])[CH2:3][O:4][C:5]2([C:13]3[C:8](=[CH:9][CH:10]=[C:11]([N+:14]([O-:16])=[O:15])[CH:12]=3)[N:7]([CH2:24][C:25]([O:27][CH3:28])=[O:26])[C:6]2=[O:17])[O:18][CH2:19]1

参加物

5

反応物 3

HCID 24758Sodium hydrideHCID 60984Methyl bromoacetateHCID 154073515',5'-Dimethyl-5-nitrospiro[indoline-3,2'-[1,3]dioxan]-2-one

生成物 1

HCID 86681647Methyl 2-(5,5-dimethyl-5'-nitro-2'-oxospiro[[1,3]dioxane-2,3'-indoline]-1'-yl)acetate収率 84%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
0 °C

実験手順

Crude 5,5-dimethyl-5′-nitrospiro[[1,3]dioxane-2,3′-indolin]-2′-one (obtained as described in Example 17, Step 1) (361 mg) was dissolved in dry DMF (11 ml) and cooled to 0° C.; NaH (60% w/w dispersion in mineral oil, 83 mg, 2.076 mmol) was added; and the mixture was stirred at 0° C. for 10 minutes (the reaction turned dark orange). Methyl 2-bromoacetate (0.144 ml, 1.557 mmol) was then added, the reaction was warmed to room temperature and stirred for 3 hours. The solvent was evaporated, water was added and extracted with EtOAc; the combined organic layers were dried over Na2SO4, filtered and evaporated. The crude was purified by flash chromatography on silica gel cartridge (petroleum ether:EtOAc from 95:5 to 85:15) affording methyl 2-(5,5-dimethyl-5′-nitro-2′-oxospiro[[1,3]dioxane-2,3′-indoline]-1′-yl)acetate (344 mg, 0.982 mmol, 84% yield). MS/ESI+ 351.0 [MH]+.

後処理

  1. temperaturethe reaction was warmed to room temperature
  2. stirringstirred for 3 hours
  3. customThe solvent was evaporated
  4. additionwater was added
  5. extractionextracted with EtOAc
  6. dry with materialthe combined organic layers were dried over Na2SO4
  7. filtrationfiltered
  8. customevaporated
  9. customThe crude was purified by flash chromatography on silica gel cartridge (petroleum ether:EtOAc from 95:5 to 85:15)

出典と根拠

ORDレコード
ord-157acb5f71bb4069870ac73177abad0e
出典データセット
uspto-grants-2015_05
特許番号
US09024027B2

反応ノート

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