Hydrochloric Acid → 2-(1,3-Dioxo-5-(pyridin-3-ylmethoxy)isoindolin-2-yl)acetic acid hydrochloride

HRID 571333ノート

反応式

HRID 571333 の反応式
[O:1]=[C:2]1[C:10]2[C:5](=[CH:6][C:7]([O:11][CH2:12][C:13]3[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=3)=[CH:8][CH:9]=2)[C:4](=[O:19])[N:3]1[CH2:20][C:21]([O:23]C)=[O:22].[ClH:25]>C1COCC1>[ClH:25].[O:1]=[C:2]1[C:10]2[C:5](=[CH:6][C:7]([O:11][CH2:12][C:13]3[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=3)=[CH:8][CH:9]=2)[C:4](=[O:19])[N:3]1[CH2:20][C:21]([OH:23])=[O:22]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 86681748Methyl 2-(1,3-dioxo-5-(pyridin-3-ylmethoxy)isoindolin-2-yl)acetate

生成物 1

HCID 866817492-(1,3-Dioxo-5-(pyridin-3-ylmethoxy)isoindolin-2-yl)acetic acid hydrochloride収率 90.1%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of methyl 2-(1,3-dioxo-5-(pyridin-3-ylmethoxy)isoindolin-2-yl)acetate (56 mg, 0.172 mmol) in THF (3 ml), aqueous 6N HCl (2002 μL, 12.01 mmol) was added, and the reaction mixture was stirred for 16 hours at room temperature and then heated at 50° C. for 5 hours. The volatiles were removed under vacuum and the crude was dried yielding 2-(1,3-dioxo-5-(pyridin-3-ylmethoxy)isoindolin-2-yl)acetic acid hydrochloride (54 mg, 0.155 mmol, 90% yield, MS/ESI+ 313.0 [MH]+).

後処理

  1. temperatureheated at 50° C. for 5 hours
  2. customThe volatiles were removed under vacuum
  3. customthe crude was dried

出典と根拠

ORDレコード
ord-f62ee2c13e5a41139ef7b68bf9d1afcf
出典データセット
uspto-grants-2015_05
特許番号
US09024027B2

反応ノート

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