Acetic Acid → cis-3-(Boc-amino)-5-methylpiperidine
反応式
[CH3:1][C:2]1[CH:3]=[C:4]([NH:8][C:9](=[O:15])[O:10][C:11]([CH3:14])([CH3:13])[CH3:12])[CH:5]=[N:6][CH:7]=1.CC(O)=O>[Pt]>[CH3:1][C@@H:2]1[CH2:7][NH:6][CH2:5][C@H:4]([NH:8][C:9](=[O:15])[O:10][C:11]([CH3:14])([CH3:13])[CH3:12])[CH2:3]1参加物
4
実験手順
A Parr bottle was charged with tert-butyl 5-methylpyridin-3-ylcarbamate (365 mg, 1.75 mmol) and AcOH (10 mL, 0.17 mol). Nitrogen was bubbled through the mixture for several minutes with stirring before 5% Pt/C (365 mg, 0.027 mol) was added, and the bottle was placed under an atmosphere of hydrogen (60 psi) for 24 h. The mixture was filtered and the solvent concentrated in vacuo to afford the title intermediate as an oil, which was used without further purification.
後処理
- customNitrogen was bubbled through the mixture for several minutes
- additionwas added
- filtrationThe mixture was filtered
- concentrationthe solvent concentrated in vacuo
出典と根拠
- ORDレコード
- ord-b516faf86b614a5090383822fc37a2aa
- 出典データセット
- uspto-grants-2015_05
- 特許番号
- US09029359B2
反応ノート
読み込み中…