(2-benzyloxy-7,8-dihydro-4H,6H-1,5,8a-triaza-azulen-5-yl)-(4-fluoro-phenyl)-methanone → HCID 178519626、化合物

HRID 571728

反応式

HRID 571728 の反応式
C([O:8][C:9]1[CH:18]=[C:17]2[N:11]([CH2:12][CH2:13][CH2:14][N:15]([C:19]([C:21]3[CH:26]=[CH:25][C:24]([F:27])=[CH:23][CH:22]=3)=[O:20])[CH2:16]2)[N:10]=1)C1C=CC=CC=1>CCOC(C)=O.CN(C=O)C.[OH-].[OH-].[Pd+2]>[F:27][C:24]1[CH:25]=[CH:26][C:21]([C:19]([N:15]2[CH2:14][CH2:13][CH2:12][N:11]3[C:17](=[CH:18][C:9]([OH:8])=[N:10]3)[CH2:16]2)=[O:20])=[CH:22][CH:23]=1

参加物

4

反応物 1

HCID 86706495(2-benzyloxy-7,8-dihydro-4H,6H-1,5,8a-triaza-azulen-5-yl)-(4-fluoro-phenyl)-methanone

生成物 1

HCID 178519626HCID 178519626、化合物収率 93%

試薬・触媒・溶媒 2

HCID 9942167Palladium hydroxide触媒HCID 22989253N,N-dimethylformamide ethyl acetate溶媒

実験手順

A solution of (2-benzyloxy-7,8-dihydro-4H,6H-1,5,8a-triaza-azulen-5-yl)-(4-fluoro-phenyl)-methanone (0.902 g, 2.47 mmol) in a mixture of AcOEt/DMF (25/25 mL) was hydrogenated in a H-Cube reactor (1.5 ml/min, 70 mm, Pd(OH)2/C cartridge, full H2 mode, 80° C., 1 cycle). The solvents were evaporated in vacuo to yield (4-Fluoro-phenyl)-(2-hydroxy-7,8-dihydro-4H,6H-1,5,8a-triaza-azulen-5-yl)-methanone (0.63 g, 93% yield) as a colorless oil, that was used in the next step without further purification.

後処理

  1. customwas hydrogenated in a H-Cube reactor
  2. customThe solvents were evaporated in vacuo

出典と根拠

ORDレコード
ord-814ca853f9ba4a78a4b73d309bc5f3b8
出典データセット
uspto-grants-2015_05
特許番号
US09029366B2

関連ノート

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