1-[4-(Benzyloxy)phenyl]-3-ethyl-1H-pyrazolo[3,4-b]pyridine → 4-(3-Ethyl-1H-pyrazolo[3,4-b]pyridin-1-yl)phenol

HRID 572174ノート

反応式

HRID 572174 の反応式
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([N:15]2[C:19]3=[N:20][CH:21]=[CH:22][CH:23]=[C:18]3[C:17]([CH2:24][CH3:25])=[N:16]2)=[CH:11][CH:10]=1)C1C=CC=CC=1>[Pd].C(O)C>[CH2:24]([C:17]1[C:18]2[C:19](=[N:20][CH:21]=[CH:22][CH:23]=2)[N:15]([C:12]2[CH:13]=[CH:14][C:9]([OH:8])=[CH:10][CH:11]=2)[N:16]=1)[CH3:25]

参加物

4

反応物 1

HCID 867049821-[4-(Benzyloxy)phenyl]-3-ethyl-1H-pyrazolo[3,4-b]pyridine

生成物 1

HCID 867049834-(3-Ethyl-1H-pyrazolo[3,4-b]pyridin-1-yl)phenol収率 91.8%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A mixture of 1-[4-(benzyloxy)phenyl]-3-ethyl-1H-pyrazolo[3,4-b]pyridine (300 mg), 10% palladium on carbon (containing water (50%), 97 mg) and ethanol (10 ml) was vigorously stirred under a hydrogen atmosphere at room temperature for 5 hr. The reaction mixture was filtered and the filtrate was concentrated to give the title compound (200 mg).

後処理

  1. filtrationThe reaction mixture was filtered
  2. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-f2f8545161374690b7943275a958663c
出典データセット
uspto-grants-2015_05
特許番号
US09029388B2

反応ノート

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