Acetic Acid → 4-Amino-2-fluorobenzoic acid

HRID 57226

反応式

HRID 57226 の反応式
[F:1][C:2]1[CH:10]=[C:9]([N+:11]([O-])=O)[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].C(O)(=O)C>[Pd].CO>[NH2:11][C:9]1[CH:8]=[CH:7][C:3]([C:4]([OH:6])=[O:5])=[C:2]([F:1])[CH:10]=1

参加物

5

反応物 2

HCID 176Acetic AcidHCID 3026792-Fluoro-4-nitrobenzoic acid

生成物 1

HCID 3026804-Amino-2-fluorobenzoic acid収率 102.7%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

To a solution of 2-fluoro-4-nitrobenzoic acid (1.0 g, 5.4 mmol) in 20 mL of a mixture of acetic acid and methanol (1:1), was added a catalytic amount of palladium on charcoal (25 mg). The reaction was stirred under an atmosphere of hydrogen gas at room temperature overnight. The mixture was then filtered through celite and the solvent was removed by evaporation to yield 0.86 g (100%) of the title compound as a cream coloured solid.

後処理

  1. filtrationThe mixture was then filtered through celite
  2. customthe solvent was removed by evaporation

出典と根拠

ORDレコード
ord-2272ef503ec54d5b831c7c1d91da81fd
出典データセット
uspto-grants-2016_09
特許番号
US09434720B2

関連ノート

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