m-Chloroperbenzoic acid → 4-Cyclopropyl-3-iodopyridine 1-oxide
反応式
ClC1C=CC=C(C(OO)=[O:9])C=1.[CH:12]1([C:15]2[CH:20]=[CH:19][N:18]=[CH:17][C:16]=2[I:21])[CH2:14][CH2:13]1>C(Cl)Cl>[CH:12]1([C:15]2[CH:20]=[CH:19][N+:18]([O-:9])=[CH:17][C:16]=2[I:21])[CH2:14][CH2:13]1参加物
4
実験手順
m-Chloroperbenzoic acid (408 mg, 2.36 mmol) was added to the solution of 4-cyclopropyl-3-iodopyridine (I-30a: 200 mg. 0.816 mmol) in DCM (10 mL) and the resulting mixture was stirred at room temperature for 3 hours. The reaction was monitored by TLC. The reaction mixture was quenched with ice and diluted with DCM. The organic layer was washed with dilute NaOH solution, water and brine solution, dried over sodium sulphate and concentrated to afford 200 mg of the product (94.7% yield).
後処理
- customThe reaction mixture was quenched with ice
- additiondiluted with DCM
- washThe organic layer was washed with dilute NaOH solution, water and brine solution
- dry with materialdried over sodium sulphate
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-40ca9718f9de439f8c86ae22bbbd84ad
- 出典データセット
- uspto-grants-2015_05
- 特許番号
- US09029399B2
反応ノート
読み込み中…