Methylamine → HCID 32890706、化合物

HRID 572692

反応式

HRID 572692 の反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5](=[O:13])[N:6]([CH2:8][C:9](OC)=[O:10])[CH:7]=1.[CH3:14][NH2:15]>C1COCC1>[Br:1][C:2]1[CH:3]=[CH:4][C:5](=[O:13])[N:6]([CH2:8][C:9]([NH:15][CH3:14])=[O:10])[CH:7]=1

参加物

4

反応物 2

HCID 6329MethylamineHCID 28834262methyl 2-(5-bromo-2-oxopyridin-1(2H)-yl)acetate

生成物 1

HCID 32890706HCID 32890706、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of methyl 2-(5-bromo-2-oxopyridin-1(2H)-yl)acetate (0.5 g, 1.92 mmol, WO 2009134400) in 2M solution of Methyl amine in THF (5 mL) was stirred at RT for 16 h. The separated solid is collected by filtration and dried under vacuum to afford 2-(5-bromo-2-oxopyridin-1(2H)-yl)-N-methylacetamide as off-white solid, 0.35 g (74%), 1H NMR (400 MHz, DMSO): 8.09 (1H, d, J=4.4 Hz), 7.93 (1H, d, J=2.4 Hz), 7.54 (1H, dd, J=3.0, 9.8 Hz), 6.36 (1H, d, J=9.8 Hz), 4.47 (2H, s), 2.61 (3H, d, J=4.9 Hz). ES-MS: 247.1 (M+2H).

後処理

  1. filtrationThe separated solid is collected by filtration
  2. customdried under vacuum

出典と根拠

ORDレコード
ord-dd1d11926b3c4470b238918959edb734
出典データセット
uspto-grants-2015_05
特許番号
US09029409B2

関連ノート

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