Methylamine → HCID 178483385、化合物

HRID 57282ノート

反応式

HRID 57282 の反応式
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10]1[C:14]([CH2:15][CH2:16][CH2:17]Br)=[N:13][NH:12][C:11]=1[NH2:19].[CH3:20][NH2:21]>C1COCC1>[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10]1[C:14]([CH2:15][CH2:16][CH2:17][NH:21][CH3:20])=[N:13][NH:12][C:11]=1[NH2:19]

参加物

4

反応物 2

HCID 6329MethylamineHCID 178509116HCID 178509116、化合物

生成物 1

HCID 178483385HCID 178483385、化合物収率 32%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A mixture of 4-benzothiazol-2-yl-5-(3-bromopropyl)-2H-pyrazol-3-ylamine (130 mg, 0.39 mmol) and methylamine (5 mL of a 2 M solution in THF, 10 mmol) was stirred at room temperature for 60 hrs. The resulting solid was isolated by filtration, washed with THF, and then with water. The product was air dried to yield 38 mg (32%) of the title compound as an off white solid. MS (m/z, ES+): 288.2 (M+1, 100%).

後処理

  1. customThe resulting solid was isolated by filtration
  2. washwashed with THF
  3. customdried

出典と根拠

ORDレコード
ord-a7b93501c10844e5a3d77d0eafb4e72b
出典データセット
uspto-grants-2016_09
特許番号
US09434720B2

反応ノート

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