O-Phenylenediamine → 1H-benzimidazol-2-yl(3-bromophenyl)methanol

HRID 572827ノート

反応式

HRID 572827 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]([OH:12])[C:9](O)=O)[CH:5]=[CH:6][CH:7]=1.[C:13]1([NH2:20])[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[NH2:19]>>[NH:19]1[C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=2[N:20]=[C:9]1[CH:8]([C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([Br:1])[CH:3]=1)[OH:12]

参加物

3

反応物 2

HCID 7243O-PhenylenediamineHCID 27570282-(3-Bromophenyl)-2-hydroxyacetic acid

生成物 1

HCID 132601701H-benzimidazol-2-yl(3-bromophenyl)methanol

実験手順

A mixture of (3-bromophenyl)hydroxyacetic acid (20 g) and ortho-phenylenediamine (9.36 g) in 5N aqueous hydrochloric solution (100 mL) is heated under reflux for 4 h and cooled back to room temperature. The precipitate is separated by filtration, rinsed with acetonitrile and dried under vacuum with phosphorus pentoxide et give 1H-benzimidazol-2-yl(3-bromophenyl)methanol as a white crystalline solid used without further purification.

後処理

  1. temperatureis heated
  2. temperatureunder reflux for 4 h
  3. customThe precipitate is separated by filtration
  4. washrinsed with acetonitrile
  5. dry with materialdried under vacuum with phosphorus pentoxide et

出典と根拠

ORDレコード
ord-0b5957c71c9448048fadb9792c2876f3
出典データセット
uspto-grants-2015_05
特許番号
US09029357B2

反応ノート

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