Hydrochloric Acid → HCID 86719109、化合物
反応式
[C:1]([C:3]1[CH:4]=[CH:5][C:6]([CH2:9][C:10]([O:12][CH3:13])=[O:11])=[N:7][CH:8]=1)#[N:2].[ClH:14]>CO.[Pd]>[Cl-:14].[CH3:13][O:12][C:10](=[O:11])[CH2:9][C:6]1[N:7]=[CH:8][C:3]([CH2:1][NH3+:2])=[CH:4][CH:5]=1参加物
5
実験手順
To a solution of methyl 2-(5-cyanopyridin-2-yl)acetate (1.2 g, 6.8 mmol) in methanol (20 ml) was added hydrogen chloride in methanol (4 M, 20 ml), and then Pd/C (200 mg). Then the reaction mixture was hydrogenated under hydrogen atmosphere overnight. The reaction mixture was filtered, the filtrate was concentrated to give the crude product and was washed by ethyl acetate to give the desired product. LC-MS: m/z (M+H)=181.5
後処理
- filtrationThe reaction mixture was filtered
- concentrationthe filtrate was concentrated
- customto give the crude product
- washwas washed by ethyl acetate
出典と根拠
- ORDレコード
- ord-38f2c37d53e74c9b8eea0362ab7f6988
- 出典データセット
- uspto-grants-2015_05
- 特許番号
- US09029531B2
反応ノート
読み込み中…