Methyl (5-nitropyridin-2-yl)acetate → Methyl 2-(5-aminopyridin-2-yl)acetate
反応式
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([CH2:10][C:11]([O:13][CH3:14])=[O:12])=[N:8][CH:9]=1)([O-])=O>CO.[Pd]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([CH2:10][C:11]([O:13][CH3:14])=[O:12])=[N:8][CH:9]=1参加物
4
実験手順
The solution of methyl 2-(5-nitropyridin-2-yl)acetate (500 mg, 2.5 mmol) and Pd/C (50 mg) in methanol (20 mL) was stirred under H2 at room temperature for 3 h. Then, the reaction mixture was filtered and evaporated under reduced pressure to get desired product for the next step without further purification.
後処理
- filtrationThen, the reaction mixture was filtered
- customevaporated under reduced pressure
出典と根拠
- ORDレコード
- ord-04132ee18ea14776832296a6aeed03fb
- 出典データセット
- uspto-grants-2015_05
- 特許番号
- US09029531B2
反応ノート
読み込み中…