1,3-Dibromopropane → 1,3-Bis(4-fluoro-2-iodophenoxy)propane

HRID 572953ノート

反応式

HRID 572953 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[C:4]([I:9])[CH:3]=1.Br[CH2:11][CH2:12][CH2:13]Br.[C:15](=[O:18])([O-])[O-].[K+].[K+]>CC(C)=O>[F:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:11][CH2:12][CH2:13][O:18][C:15]2[CH:6]=[CH:7][C:2]([F:1])=[CH:3][C:4]=2[I:9])=[C:4]([I:9])[CH:3]=1

参加物

5

反応物 3

HCID 80011,3-DibromopropaneHCID 11430Potassium CarbonateHCID 101714174-Fluoro-2-iodophenol

生成物 1

HCID 667805951,3-Bis(4-fluoro-2-iodophenoxy)propane

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

To a solution of 15.00 g (63.03 mmol) of 4-fluoro-2-iodophenol (P7), Preparation 7 and 6.40 g (31.68 mmol) of 1,3-dibromopropane in 200 mL of acetone add 26.00 g (188.4 mmol) of potassium carbonate. Reflux the resulting reaction mixture for 24 hours. Cool the reaction mixture to room temperature, filter it, and concentrate the filtrate by rotary evaporation. Crystallize the resulting solid from acetonitrile to yield 12.00 g (74%) of (P8) as a white crystalline solid.

後処理

  1. temperatureReflux
  2. customthe resulting reaction mixture for 24 hours
  3. filtrationfilter it
  4. concentrationconcentrate the filtrate
  5. customby rotary evaporation
  6. customCrystallize the resulting solid from acetonitrile
  7. customto yield 12.00 g (74%) of (P8) as a white crystalline solid

出典と根拠

ORDレコード
ord-d97b5df56a5a4d84ba81625083555a2a
出典データセット
uspto-grants-2015_05
特許番号
US09029487B2

反応ノート

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