Tetrabutylammonium Fluoride → 3-Ethynylimidazo[1,2-b]pyridazine

HRID 572985ノート

反応式

HRID 572985 の反応式
C[Si]([C:5]#[C:6][C:7]1[N:11]2[N:12]=[CH:13][CH:14]=[CH:15][C:10]2=[N:9][CH:8]=1)(C)C.[F-].C([N+](CCCC)(CCCC)CCCC)CCC>C1COCC1>[C:6]([C:7]1[N:11]2[N:12]=[CH:13][CH:14]=[CH:15][C:10]2=[N:9][CH:8]=1)#[CH:5]

参加物

4

反応物 2

HCID 2724141Tetrabutylammonium FluorideHCID 667355693-((Trimethylsilyl)ethynyl)imidazo[1,2-b]pyridazine

生成物 1

HCID 468387603-Ethynylimidazo[1,2-b]pyridazine収率 94.4%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of 3-((trimethylsilyl)ethynyl) imidazo[1,2-b]pyridazine (28.46 g, 0.132 mol) in 200 mL of THF was added 145 mL (0.145 mol) of tetrabutylammonium fluoride (1.0M in THF) at ambient temperature. The solution was stirred for 15 min, concentrated, and the crude product purified by silica gel flash chromatography (eluted with 0-5% MeOH/DCM) to provide 17.84 g of product.

後処理

  1. concentrationconcentrated
  2. customthe crude product purified by silica gel flash chromatography (eluted with 0-5% MeOH/DCM)

出典と根拠

ORDレコード
ord-7691fb09671b4b11951e1fb3f4bc8217
出典データセット
uspto-grants-2015_05
特許番号
US09029533B2

反応ノート

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