2,3-Difluoro-4-nitroanisole → 2,3-Difluoro-4-nitrophenol
反応式
[F:1][C:2]1[C:7]([F:8])=[C:6]([N+:9]([O-:11])=[O:10])[CH:5]=[CH:4][C:3]=1[O:12]C>Br.C(O)(=O)C>[F:1][C:2]1[C:7]([F:8])=[C:6]([N+:9]([O-:11])=[O:10])[CH:5]=[CH:4][C:3]=1[OH:12]参加物
4
実験手順
A solution of 2,3-difluoro-4-nitroanisole (10 g) in 48% HBr (60 mL) and 30% HBr in acetic acid (30 mL) was stirred at 120° C. overnight. The mixture was cooled to room temperature and extracted with ethyl acetate (3×200 mL) and the combined extracts were washed with brine and dried over Na2SO4. Filtration and evaporation of the solvent gave the product.
後処理
- extractionextracted with ethyl acetate (3×200 mL)
- washthe combined extracts were washed with brine
- dry with materialdried over Na2SO4
- filtrationFiltration and evaporation of the solvent
- customgave the product
出典と根拠
- ORDレコード
- ord-b81a9c3c8ff646d7a2c7a08c2716159b
- 出典データセット
- uspto-grants-2015_05
- 特許番号
- US09029404B2
反応ノート
読み込み中…