Methanol → 6-Methoxy-1H-indol-5-ol

HRID 573094ノート

反応式

HRID 573094 の反応式
C([O:8][C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][C:17]=1[O:18][CH3:19])[NH:14][CH:13]=[CH:12]2)C1C=CC=CC=1.CO.[H][H]>[OH-].[OH-].[Pd+2].C(OCC)(=O)C>[CH3:19][O:18][C:17]1[CH:16]=[C:15]2[C:11]([CH:12]=[CH:13][NH:14]2)=[CH:10][C:9]=1[OH:8]

参加物

6

反応物 3

HCID 887MethanolHCID 2608005-Benzyloxy-6-methoxyindoleHCID 178418361HCID 178418361、化合物

生成物 1

HCID 1649576-Methoxy-1H-indol-5-ol

試薬・触媒・溶媒 2

HCID 9942167Palladium hydroxide触媒HCID 8857Ethyl Acetate溶媒

実験手順

5-(benzyloxy)-6-methoxy-1H-indole (3.00 g) was added to methanol (100 mL) and ethyl acetate (100 mL) in a pressure bottle. Palladium hydroxide on carbon (0.832 g,) was added and the solution was shaken under 30 psi of hydrogen at room temperature for 40 minutes. The mixture was filtered through a nylon membrane, the solvent removed under vacuum, the residue taken up in ethyl acetate, the solution was filtered over a pad of silica gel, and the solvent was removed from the filtrate under vacuum.

後処理

  1. filtrationThe mixture was filtered through a nylon membrane
  2. customthe solvent removed under vacuum
  3. filtrationthe solution was filtered over a pad of silica gel
  4. customthe solvent was removed from the filtrate under vacuum

出典と根拠

ORDレコード
ord-edcdb6c88f4d4980aab0415a1d1c465a
出典データセット
uspto-grants-2015_05
特許番号
US09029404B2

反応ノート

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