2-methyl-1H-indol-5-ol → 2-(2-Amino-pyridin-4-yloxy)-4-fluoro-benzoic acid methyl ester

反応式

F[C:2]1[CH:12]=[C:11]([F:13])[CH:10]=[CH:9][C:3]=1[C:4]([O:6][CH2:7]C)=[O:5].[NH2:14][C:15]1[CH:20]=[C:19]([OH:21])[CH:18]=[CH:17][N:16]=1.CC1NC2C(C=1)=CC(O)=CC=2>>[CH3:7][O:6][C:4](=[O:5])[C:3]1[CH:9]=[CH:10][C:11]([F:13])=[CH:12][C:2]=1[O:21][C:19]1[CH:18]=[CH:17][N:16]=[C:15]([NH2:14])[CH:20]=1

参加物

反応物 3

HCID 833362-methyl-1H-indol-5-ol

HCID 2737170Benzoic acid, 2,4-difluoro-, ethyl ester

HCID 178507942HCID 178507942、化合物

生成物 1

HCID 672278842-(2-Amino-pyridin-4-yloxy)-4-fluoro-benzoic acid methyl ester

実験手順

The title compound was prepared by substituting methyl 2,4-difluorobenzoate for ethyl 2,4-difluorobenzoate and 2-aminopyridin-4-ol for 2-methyl-5-indolol in EXAMPLE 3A, except here heating was at 130° C.